Adding to this meme, here are some PyCon 2010 talks I'm particularly looking forward to:
  1. "Creating RESTful Web services with restish" by Grig Gheorghiu.
  2. "Python Testing Patterns", by Aaron Maxwell.
  3. "To relate or not to relate, that is the question", by Mark Ramm.
  4. "Turtles All The Way Down: Demystifying Deferreds, Decorators, and Declarations", by Glyph Lefkowitz.
  5. "VisTrails: A Python-Based Scientific Workflow and Provenance System", by Juliana Friere.
  6. "On the Subject of Source Code", by Ian Bicking. (I have strong opinions :-)
See also here, here, and here.